Summary of findings
Say what you saw, what you felt, and what the organs measured — then name the pattern and its likely cause and complications.
I examined the abdomen of a middle-aged man who is jaundiced. The abdomen is uniformly distended and moves with respiration, with dilated superficial veins radiating from the umbilicus. It is not tender. The liver is not palpable and the span is reduced to 6 cm. The spleen is palpable 8 cm below the left costal margin, firm and smooth. There is shifting dullness. The kidneys are not ballotable, bowel sounds are normal and there are no bruits. He has palmar erythema, spider naevi and gynaecomastia. These findings are in keeping with decompensated chronic liver disease with portal hypertension.
- Liver: centimetres below the right costal margin in the midclavicular line, plus the percussed span; consistency, surface, edge, tenderness, bruit
- Spleen: centimetres below the left costal margin, measured towards the right iliac fossa along its line of enlargement; consistency; whether you felt a notch
- Ascites: how you showed it — shifting dullness for moderate, fluid thrill for tense
Differential diagnoses
| Pattern | Causes to offer |
|---|---|
| Hepatomegaly with ascites | Hepatocellular carcinoma, metastases, right heart failure, Budd–Chiari syndrome, abdominal tuberculosis |
| Shrunken liver, splenomegaly and ascites | Cirrhosis with portal hypertension — hepatitis B or C, alcohol, autoimmune, metabolic, herbal and drug injury |
| Massive splenomegaly | Chronic myeloid leukaemia, myelofibrosis, hyperreactive malarial splenomegaly, visceral leishmaniasis, lymphoma |
| Hepatosplenomegaly without ascites | Malaria, lymphoma and leukaemia, haemoglobinopathies, HIV, schistosomiasis |
| Bilateral ballotable masses | Polycystic kidneys, bilateral hydronephrosis, amyloidosis |
More detail: Massive splenomegaly, Hard nodular hepatomegaly with ascites, Shrunken liver with ascites, and Liver tests and treatment by cause.
Investigations
- Blood: full blood count and film, liver function with albumin and INR, urea, electrolytes and creatinine, glucose
- Viral and immune markers: HBsAg, anti-HCV, HIV test with consent, autoantibodies where relevant
- Tumour markers: alpha-fetoprotein
- Imaging: abdominal ultrasound with Doppler; contrast CT or MRI for a mass
- Ascitic tap: cell count, albumin for the serum-ascites albumin gradient, protein, culture, cytology, ADA
- Endoscopy: for varices in portal hypertension
Treatment
- Treat the cause: antivirals for hepatitis B or C, stopping alcohol, specific treatment of blood disorders
- Ascites: salt restriction, spironolactone with or without furosemide, paracentesis with albumin
- Prevent and treat complications: variceal bleeding, spontaneous bacterial peritonitis, encephalopathy
- Nutrition, vaccination, avoiding NSAIDs and herbal remedies
Examiner questions
References
- Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, et al., eds. Harrison's Principles of Internal Medicine. 22nd ed. New York: McGraw Hill; 2025.