Summary of findings
I examined the breasts of a 45-year-old woman with a chaperone present. With her arms by her sides, the right breast is higher than the left, with skin dimpling in the upper outer quadrant that becomes more obvious with the arms raised. The nipples are normal. On palpation there is a single 4 × 3 cm lump in the upper outer quadrant of the right breast at 10 o'clock, 5 cm from the nipple. It is non-tender, hard, with an irregular surface and ill-defined edge. It is tethered to the skin but not fixed to pectoralis major or the chest wall. There are two firm, mobile right axillary lymph nodes in the anterior group, the larger 1.5 cm. The left breast and axilla and both supraclavicular fossae are normal. The liver is not enlarged, and there is no spinal tenderness. My clinical impression is carcinoma of the right breast, clinically T2 N1 M0. I would arrange triple assessment.
Differential diagnoses
| Lump | Features that point to it |
|---|---|
| Carcinoma | Over 35, hard, irregular, fixed, skin or nipple changes, axillary nodes |
| Fibroadenoma | Under 30, smooth, rubbery, highly mobile ("breast mouse") |
| Phyllodes tumour | Over 40, large, rapidly growing, smooth and lobulated, stretched shiny skin |
| Cyst | 35–55, smooth, well defined, may be tender, can transilluminate |
| Fat necrosis | History of trauma, hard, may tether skin — mimics cancer |
| Breast abscess | Lactating, red, hot, tender, fluctuant |
| Periductal mastitis | Smoker, subareolar mass, nipple retraction, fistula |
| Tuberculous mastitis | Sinus, axillary nodes, systemic symptoms |
| Lipoma, sebaceous cyst | Soft or superficial, attached to skin with a punctum |
Investigations
Triple assessment — all three together:
- Clinical examination (as above)
- Imaging — ultrasound under 35 years; mammography (two views) plus ultrasound aged 35 and over; ultrasound of the axilla
- Pathology — ultrasound-guided core needle biopsy for histology, grade and receptors (ER, PR, HER2); FNA or core biopsy of abnormal axillary nodes
If any of the three is suspicious, the lump is treated as malignant until proved otherwise.
Treatment
See Breast cancer staging and treatment and Benign breast disease.
Examiner questions
References
- O'Connell PR, McCaskie AW, Sayers RD, eds. Bailey & Love's Short Practice of Surgery. 28th ed. Boca Raton: CRC Press; 2023.