Summary of findings
I examined a 58-year-old man with an ulcer on his left leg. There is a single ulcer, 6 × 4 cm, on the medial aspect of the lower third of the left leg, 5 cm above the medial malleolus. It is oval with a gently sloping edge. The floor has pink granulation tissue with patches of slough and a small amount of serous discharge. The surrounding skin is pigmented and indurated, with eczema and pitting oedema, and there are varicose veins along the course of the great saphenous vein. The ulcer is not fixed to the tibia. The inguinal lymph nodes are not enlarged. All peripheral pulses are palpable, and sensation is intact. These findings suggest a venous ulcer. I would like to measure his ankle–brachial pressure index.
Differential diagnoses
The edge tells you the cause
| Edge | Typical cause |
|---|---|
| Sloping, shelving | Healing ulcer, venous ulcer |
| Punched out | Arterial, neuropathic (diabetic, leprosy), gummatous syphilis |
| Undermined | Tuberculosis, pressure sore, Buruli ulcer (Mycobacterium ulcerans) |
| Rolled, pearly | Basal cell carcinoma |
| Raised, everted, indurated | Squamous cell carcinoma (including Marjolin's ulcer) |
Chronic leg ulcer — where it is and what goes with it
| Type | Site | Features |
|---|---|---|
| Venous | Gaiter area, above the medial malleolus | Shallow, sloping edge, painless or aching, pigmentation, lipodermatosclerosis, varicose veins, normal pulses |
| Arterial | Toes, heel, dorsum of foot, shin | Punched out, painful (worse on elevation), pale floor, absent pulses, cold foot |
| Neuropathic | Pressure points — plantar metatarsal heads, heel | Punched out with callus, painless, warm foot, absent sensation |
| Sickle cell | Around the malleoli | Painful, recurrent, in young adults with sickle cell disease |
| Tropical phagedenic | Lower leg in the malnourished, after minor trauma | Rapid, painful, foul slough |
| Buruli | Limbs, in people near slow-flowing water | Painless nodule becoming a large ulcer with undermined edges |
| Malignant (Marjolin) | In a chronic scar, burn or long-standing ulcer | Everted, indurated edge, bleeds easily, growing, may involve nodes |
| Vasculitic or pyoderma gangrenosum | Anywhere | Purple undermined edge, rheumatoid arthritis or inflammatory bowel disease |
Investigations
- Swab only if the ulcer looks infected; take tissue for culture including acid-fast bacilli and M. ulcerans PCR when suspected
- Wedge biopsy of the edge (including normal skin) for any ulcer that is atypical, not healing after 12 weeks of good care, or has a raised edge
- Full blood count, glucose or HbA1c, ESR or CRP, haemoglobin electrophoresis, albumin, HIV serology and syphilis serology when indicated
- Ankle–brachial pressure index — below 0.8 means arterial disease; above 1.3 means incompressible, calcified vessels (diabetes, kidney disease)
- Venous duplex — superficial and deep reflux or obstruction
- X-ray or MRI of the underlying bone — osteomyelitis
Treatment
- Treat the cause — compression and venous ablation, revascularisation, off-loading and glucose control, antibiotics
- Wound bed preparation: debride slough, control infection and exudate, keep moist
- Nutrition, mobility and pain relief
- Skin grafting once the bed is healthy
- Wide excision for malignancy; see Marjolin's ulcer
Examiner questions
References
- O'Connell PR, McCaskie AW, Sayers RD, eds. Bailey & Love's Short Practice of Surgery. 28th ed. Boca Raton: CRC Press; 2023.